The Windows DisableAntiSpyware Registry detection rule specifies the monitoring of changes to the registry key 'DisableAntiSpyware'. This key, when set to '0x00000001', indicates that the Windows Defender has been disabled, which is a common practice during ransomware attacks like Ryuk. Such modifications could facilitate malicious actors in bypassing critical security measures, enabling them to execute further compromise operations that may include data encryption and exfiltration. The rule utilizes the Endpoint.Registry data model from Sysmon Event IDs 12 and 13 to identify these registry modifications and alert security teams to potential threats.