This detection rule targets modifications to the Windows registry, specifically monitoring for changes to the 'DisableScanOnUpdate' setting that could disable the Windows Defender Scan On Update feature. When this setting is modified to '0x00000001', it indicates an intentional disablement of automatic scans by Windows Defender, potentially leading to increased vulnerability against malware and other threats. The rule leverages Sysmon Event IDs 12 and 13 to gather relevant event data from the registry, allowing for the identification of unauthorized or malicious alterations to key security settings. Such changes are significant as they can facilitate an attacker's ability to bypass the built-in defenses of Windows environments, thus enabling potential further compromise and persistence. The associated search query is designed to extract this information efficiently from the Endpoint Registry data model in Splunk.